Yuwiler A, Taylor A N
Neurobiochemistry Laboratory T-85, West Los Angeles Veterans Administration Medical Center Brentwood Division, CA 90073, USA.
J Pineal Res. 1995 Mar;18(2):57-61. doi: 10.1111/j.1600-079x.1995.tb00140.x.
Pineals from neonatal rats born to alcohol-fed mothers had lower unstimulated serotonin-N-acetyltransferase activity (NAT) and responded less to isoproterenol, vasoactive intestinal polypeptide, or desmethylimipramine challenge than did pineals from pups born to normal or pair-fed mothers. Group differences disappeared after the first week of life. Reduced NAT activity is coincident with elevated glucocorticoids in these pups. In contrast to these effects of chronic in utero ethanol exposure, acute ethanol addition to normal adult pineals in organ culture enhanced ISO but not VIP stimulation of NAT activity. The results suggest that the neonatal pineal is more affected by ethanol-induced activation of the adrenocortical axis during gestation than by the direct effect of ethanol on membrane fluidity.
与正常喂养或配对喂养的母亲所生幼崽的松果体相比，酒精喂养的母亲所生新生大鼠的松果体在未受刺激时血清素 - N - 乙酰转移酶活性（NAT）较低，对异丙肾上腺素、血管活性肠肽或去甲丙咪嗪刺激的反应也较小。出生后第一周后，组间差异消失。这些幼崽中NAT活性降低与糖皮质激素升高同时出现。与子宫内慢性乙醇暴露的这些影响相反，在器官培养中向正常成年松果体急性添加乙醇可增强异丙肾上腺素而非血管活性肠肽对NAT活性的刺激。结果表明，新生儿松果体在妊娠期间受乙醇诱导的肾上腺皮质轴激活的影响比受乙醇对膜流动性的直接影响更大。
