The antihypertensive effect of indapamide.

Fourteen patients with moderately severe essential hypertension were treated for 8 weeks with indapamide 2,5 mg/d. Systolic and diastolic blood pressures fell significantly from the 1st week of treatment; the rapid changes noted thereafter were described mathematically by decreasing power functions of time. Serum potassium and blood glucose values did not change significantly. Indapamide behaves as a power antihypertensive diuretic which appears safe at low doses and can be considered for the first-line treatment of essential hypertension.