Weissman S H, Cuddihy R G, Medinsky M A
Toxicol Appl Pharmacol. 1983 Mar 15;67(3):331-7. doi: 10.1016/0041-008x(83)90316-2.
We studied the distribution and retention of inhaled selenious acid and selenium metal aerosols which were similar in size and chemical form to selenium aerosols that may be produced during fossil fuel combustion. Beagle dogs were given 10 to 61 micrograms Se/kg of body weight by inhalation. Aerosols generated for the inhalation exposures were also collected and instilled into the upper respiratory tracts or stomachs of additional dogs to measure systemic absorption at these sites. Selenium-75, incorporated into the aerosols, was used to determine the Se content in the whole animal, excreta, and individual tissues as a function of time. Virtually all of the inhaled selenious acid aerosol was rapidly absorbed into the blood from the lungs, gastrointestinal tract, and the nasal membranes. Selenium metal aerosols were less rapidly absorbed. Selenium that was absorbed into the blood was translocated to the liver, kidney, spleen, and heart. Selenium-75 in these organs had a biological half-life of 30 to 40 days. Approximately 50% of the deposited Se was eliminated with a biological T1/2 of 1.2 days. Urine was the major route of excretion, accounting for 70 to 80% of the excreted Se. The long-term component of the whole-body retention function for both inhaled aerosols had a half-life of about 34 days and accounted for about 20% of the initial Se dose. The data suggested that although absorption of selenious acid into blood following inhalation was more rapid than absorption of selenium metal, once absorbed the disposition of both compounds was similar.
我们研究了吸入的亚硒酸和金属硒气溶胶的分布与滞留情况，它们在大小和化学形态上与化石燃料燃烧过程中可能产生的硒气溶胶相似。给比格犬吸入10至61微克硒/千克体重。用于吸入暴露的气溶胶也被收集起来，并灌注入其他犬的上呼吸道或胃中，以测量这些部位的全身吸收情况。掺入气溶胶中的硒-75被用于测定全动物、排泄物及各个组织中的硒含量随时间的变化。实际上，几乎所有吸入的亚硒酸气溶胶都迅速从肺、胃肠道和鼻黏膜吸收进入血液。金属硒气溶胶的吸收速度较慢。吸收进入血液的硒被转运至肝脏、肾脏、脾脏和心脏。这些器官中的硒-75的生物半衰期为30至40天。大约50%沉积的硒以1.2天的生物半衰期被清除。尿液是主要的排泄途径，占排泄硒的70%至80%。两种吸入气溶胶的全身滞留功能的长期成分的半衰期约为34天，占初始硒剂量的约20%。数据表明，尽管吸入后亚硒酸进入血液的吸收比金属硒更快，但一旦被吸收，两种化合物的处置情况相似。
