Medinsky M A, Cuddihy R G, McClellan R O
J Toxicol Environ Health. 1981 Nov-Dec;8(5-6):917-28. doi: 10.1080/15287398109530126.
Absorption of Se from the nasal passages, lungs, gastrointestinal tract, and skin was studied in Fischer-344 rats. Radiolabeled selenious acid and elemental Se particles were administered by inhalation, gavage, nasal instillation, and iv injection. Selenious acid was always absorbed into the general circulation more rapidly and to a greater extent than elemental Se. By 4 h after inhalation of selenious acid and elemental Se aerosols, 94% of the selenious acid and 57% of the elemental Se deposited in lungs was absorbed into blood. Of the selenious acid instilled into nasal passages, 18% was absorbed into blood; 16% of the elemental Se was absorbed. Gastrointestinal absorption was 87% for selenious acid and 50% for elemental Se. Selenious acid solutions were also painted onto the pelts of rats. From 10 to 30% of the selenious acid was absorbed through the skin. Following inhalation or injection of either Se compound, most of the Se was excreted in the urine. Significantly more Se appeared in feces of animals receiving elemental Se by gavage than animals receiving selenious acid. Results indicate that if people were to absorb inhaled Se from the upper respiratory tract in a manner similar to that of rats, one-third more selenious acid would be absorbed into the general circulation than elemental Se. All Se deposited in the lungs would be absorbed into blood. However, selenious acid would be absorbed more rapidly than elemental Se.
在Fischer - 344大鼠中研究了硒从鼻腔、肺部、胃肠道和皮肤的吸收情况。通过吸入、灌胃、滴鼻和静脉注射给予放射性标记的亚硒酸和元素硒颗粒。亚硒酸总是比元素硒更快且更大量地被吸收进入体循环。吸入亚硒酸和元素硒气雾剂后4小时，沉积在肺部的亚硒酸的94%和元素硒的57%被吸收进入血液。滴鼻给予的亚硒酸中有18%被吸收进入血液；元素硒的吸收比例为16%。亚硒酸的胃肠道吸收为87%，元素硒为50%。还将亚硒酸溶液涂抹在大鼠的皮毛上。10%至30%的亚硒酸通过皮肤被吸收。吸入或注射任何一种硒化合物后，大部分硒通过尿液排出。经灌胃给予元素硒的动物粪便中出现的硒明显多于给予亚硒酸的动物。结果表明，如果人类以上呼吸道吸收吸入硒的方式与大鼠相似，那么吸收进入体循环的亚硒酸将比元素硒多三分之一。沉积在肺部的所有硒都将被吸收进入血液。然而，亚硒酸的吸收速度将比元素硒更快。
