Paladino J A, Blumer N A, Maddox R R
Ther Drug Monit. 1983;5(1):135-9. doi: 10.1097/00007691-198303000-00016.
Increased clearance of theophylline after the administration of secobarbital was observed in a child receiving phenobarbital. Prior to barbiturate treatment, theophylline clearance was 4.78 ml/kg/min. Beginning 10 days after the institution of secobarbital and phenobarbital therapy, a continually increasing amount of theophylline was required to maintain therapeutic serum concentrations. After 29 days of barbiturate administration, theophylline clearance attained a peak value of 16.1 ml/kg/min, an increase of 337% from the prebarbiturate rate. During this time it was necessary to administer theophylline at a dosage four times above that usually recommended. After secobarbital was discontinued, theophylline clearance returned to 4.53 ml/kg/min. The decrease in theophylline clearance occurred while phenobarbital dosage remained stable. It is apparent that changes in secobarbital dosing were subsequently followed by changes in the clearance of theophylline.
在一名接受苯巴比妥治疗的儿童中观察到，给予司可巴比妥后茶碱清除率增加。在巴比妥类药物治疗前，茶碱清除率为4.78毫升/千克/分钟。在开始司可巴比妥和苯巴比妥治疗10天后，需要不断增加茶碱剂量以维持治疗性血清浓度。在给予巴比妥类药物29天后，茶碱清除率达到峰值16.1毫升/千克/分钟，比巴比妥类药物治疗前的速率增加了337%。在此期间，必须给予茶碱的剂量是通常推荐剂量的四倍。停用司可巴比妥后，茶碱清除率恢复到4.53毫升/千克/分钟。在苯巴比妥剂量保持稳定的情况下，茶碱清除率下降。显然，司可巴比妥剂量的变化随后伴随着茶碱清除率的变化。
