Landay R A, Gonzalez M A, Taylor J C
J Allergy Clin Immunol. 1978 Jul;62(1):27-9. doi: 10.1016/0091-6749(78)90068-4.
The effect of chronic phenobarbital administration on the pharmacokinetics of theophylline was studied in 6 healthy, nonsmoking adults. Subject compliance was verified by the determination of plasma phenobarbital levels. Following four weeks of phenobarbital administration, all six subjects showed a resultant increase in serum clearance varying from 11% to 60% with a mean increase of 34% (from 3.01 to 4.04 L/hr/1.73 M2). Theophylline appears to be metabolized more rapidly during chronic phenobarbital administration. This effect, therefore, must be taken into account when administering barbiturates to asthmatic patients for whom theophylline therapy is prescribed.
在6名健康、不吸烟的成年人中研究了长期服用苯巴比妥对茶碱药代动力学的影响。通过测定血浆苯巴比妥水平来验证受试者的依从性。在服用苯巴比妥四周后，所有6名受试者的血清清除率均有增加，增幅从11%至60%不等，平均增加34%（从3.01升至4.04升/小时/1.73平方米）。在长期服用苯巴比妥期间，茶碱的代谢似乎更快。因此，在给接受茶碱治疗的哮喘患者使用巴比妥类药物时，必须考虑到这种影响。
