Weaker F J, Sheridan P J
Acta Anat (Basel). 1983;115(3):244-51. doi: 10.1159/000145696.
The uptake and retention of radiolabelled dihydrotestosterone or one of its metabolites by both the male and female reproductive organs were examined in the baboon 2 male and 2 female baboons were injected intravenously with 1 micrograms/kg body weight of 3H-dihydrotestosterone and 2 animals, 1 male and 1 female, were injected with both labelled and 100 micrograms/kg body weight of radio-inert dihydrotestosterone. 1.5 h the injections, the animals were sacrificed and the uterus, cervix, vagina, uterine tube, labia minora, seminal vesicles, prostate, ductus deferens, and prepuce were removed and treated for autoradiography. The stratified squamous epithelia of the cervix, vagina, labia minora and prepuce demonstrated uptake of label in the germinative, but not in the superficial, cell layers. The columnar cells lining the uterine tube and cervical glands, but not the uterine glands, were labelled. In addition, the nuclei of the cells in the luminal epithelium of the prostate and seminal vesicles contained silver grains. The interstitial cells of the seminal vesicles, prostate and ductus deferens, and the smooth muscle of the prostate and ductus deferens, but not the seminal vesicles, demonstrated an uptake of radioactivity.
在狒狒身上研究了放射性标记的双氢睾酮或其一种代谢产物在雄性和雌性生殖器官中的摄取和保留情况。给2只雄性和2只雌性狒狒静脉注射1微克/千克体重的³H - 双氢睾酮，给1只雄性和1只雌性动物注射标记的和100微克/千克体重的放射性惰性双氢睾酮。注射后1.5小时，处死动物，取出子宫、宫颈、阴道、输卵管、小阴唇、精囊、前列腺、输精管和包皮，进行放射自显影处理。宫颈、阴道、小阴唇和包皮的复层鳞状上皮在生发层而非表层细胞层显示有标记摄取。输卵管和宫颈腺的柱状细胞（而非子宫腺）被标记。此外，前列腺和精囊腔上皮细胞的细胞核含有银粒。精囊、前列腺和输精管的间质细胞以及前列腺和输精管的平滑肌（而非精囊）显示有放射性摄取。
