Weaker F J, Sheridan P J
J Morphol. 1982 May;172(2):151-7. doi: 10.1002/jmor.1051720203.
The uptake and retention of radiolabeled estradiol by both the male and female reproductive organs were examined in the baboon. Two male and two female baboons were injected intracardially with 1 microgram/kg body weight of 3H-estradiol and two animals, one male and one female, were injected with both labeled and 100 micrograms/kg body weight of unlabeled estradiol. One and a half hours after the injections, the animals were sacrificed and the uterus, cervix, vagina, oviduct, seminal vesicles, and prostate gland were removed and processed for autoradiography. The stratified squamous epithelia of the cervix and vagina demonstrated a light uptake of the label in the germinative, but not in the superficial cell layers. The columnar cells lining the oviduct and uterine glands were labeled, whereas the luminal epithelium of the uterus and the glandular epithelia of the seminal vesicles and prostate gland did not sequester the tritiated steroid. The interstitial cells of all the organs studied demonstrated a moderate to heavy uptake of the radioactivity, whereas the smooth muscle cells were lightly labeled except in the vagina, in which these cells displayed a moderate number of silver grains.
在狒狒身上研究了放射性标记的雌二醇在雄性和雌性生殖器官中的摄取和保留情况。给两只雄性和两只雌性狒狒经心内注射每千克体重1微克的³H - 雌二醇，给另外两只动物（一只雄性和一只雌性）同时注射标记的和每千克体重100微克未标记的雌二醇。注射后一个半小时，处死动物，取出子宫、宫颈、阴道、输卵管、精囊和前列腺，进行放射自显影处理。宫颈和阴道的复层鳞状上皮在生发层有少量标记摄取，但表层细胞层没有。输卵管和子宫腺的柱状细胞被标记，而子宫内膜上皮以及精囊和前列腺的腺上皮没有摄取氚化类固醇。所研究的所有器官的间质细胞显示出中度至重度的放射性摄取，而平滑肌细胞只有少量标记，阴道除外，阴道中的这些细胞显示有中等数量的银颗粒。
