Alberius P
Acta Anat (Basel). 1983 Apr;115(4):310-8. doi: 10.1159/000145707.
To elucidate intramembranous bone reactions to tantalum bone markers, 0.8-mm tantalum balls were implanted in the craniofacial region of 9 male New Zealand white rabbits. After 1, 2, 4 and 16 weeks the animals were sacrificed for SEM. Implant stability for these intervals was controlled by roentgen stereophotogrammetry. Fibrocytes and deposed fibers were seen to immediately adhere to the ball surface, getting retention in its porosities. A successively increasing bony support was observed to have intimate junctions without intervening fibers or soft tissues. No apparent differences in bone reactions were seen between the neurocranial and splanchnocranial bones. Osseointegration confirmed the inertness of tantalum to bone tissue and strongly confirms its suitability for implantation in bone.
为阐明膜内骨对钽骨标记物的反应，将0.8毫米的钽球植入9只雄性新西兰白兔的颅面部区域。在1、2、4和16周后，处死动物进行扫描电子显微镜（SEM）检查。这些时间段内的植入稳定性通过X射线立体摄影测量法进行控制。可见纤维细胞和沉积的纤维立即附着于球表面，并保留在其孔隙中。观察到骨支持逐渐增加，其间有紧密连接，无纤维或软组织介入。在脑颅骨和平颅骨之间未观察到明显的骨反应差异。骨整合证实了钽对骨组织的惰性，并有力地证实了其在骨中植入的适用性。
