Aronson A S, Jonsson N, Alberius P
Skeletal Radiol. 1985;14(3):207-11. doi: 10.1007/BF00355566.
The biocompatibility of two types of radiopaque tantalum markers was evaluated histologically. Reactions to pin markers (99.9% purity) and spherical markers (95.2% purity) were investigated after 3-6 weeks in rabbits and 5-48 weeks in children with abnormal growth. Both marker types were firmly attached to bone trabeculae; this was most pronounced in rabbit bone, and no adverse macroscopic reactions were observed. Microscopically, no reactions or only slight fibrosis of bone tissue were detected, while soft tissues only demonstrated a minor inflammatory reaction. Nevertheless, the need for careful preparation and execution of marker implantations is stressed, and particularly avoidance of the use of emery in sharpening of cannulae. The bioinertness of tantalum was reconfirmed as was its suitability for use as skeletal and soft tissue radiographic markers.
对两种类型的不透射线钽标记物的生物相容性进行了组织学评估。在兔子体内3至6周以及生长异常儿童体内5至48周后，研究了对针状标记物（纯度99.9%）和球形标记物（纯度95.2%）的反应。两种标记物类型均牢固附着于骨小梁；这在兔骨中最为明显，且未观察到不良宏观反应。在显微镜下，未检测到骨组织反应或仅检测到轻微纤维化，而软组织仅表现出轻微炎症反应。尽管如此，仍强调标记物植入需要仔细准备和操作，尤其要避免在套管针锐化时使用金刚砂。钽的生物惰性再次得到证实，其作为骨骼和软组织射线照相标记物的适用性也得到了证实。
