Kimula Y, Utsuyama M, Yoshimura M, Tomonaga M
Acta Neuropathol. 1983;59(3):233-6. doi: 10.1007/BF00703209.
Two possible interpretations of the origin of Lewy bodies and adrenal bodies found in Parkinson's disease are now under discussion: a disorder of (1) catecholamine metabolism or (2) sphingomyelin lipidosis. From the electron probe microanalysis of Lewy bodies and adrenal bodies, we find that the Lewy body contains sulfur, calcium, and phosphorus, and the adrenal body also contains these three elements. Furthermore, a positive correlation was obtained between the X-ray intensity of the sulfur and the diameter of adrenal body. For Lewy bodies, this correlation was not obtained. The results suggest that a common mechanism may exist for the production of Lewy and adrenal bodies, although they differ somewhat in their accumulation of sulfur. It is considered that both structures may originate, in part, from degenerated protein containing sulfur.
（1）儿茶酚胺代谢紊乱或（2）鞘磷脂沉积症。通过对路易小体和肾上腺小体的电子探针微量分析，我们发现路易小体含有硫、钙和磷，肾上腺小体也含有这三种元素。此外，硫的X射线强度与肾上腺小体直径之间存在正相关。对于路易小体，未获得这种相关性。结果表明，尽管路易小体和肾上腺小体在硫的积累方面有所不同，但它们的产生可能存在共同机制。据认为，这两种结构可能部分源自含硫的变性蛋白质。
