Ohama E, Ikuta F
Acta Neuropathol. 1976 Apr 26;34(4):311-9. doi: 10.1007/BF00696560.
A systematic study of the central and peripheral nervous systems in 3 cases of Parkinson's disease has demonstrated that Lewy bodies are present in 27 nuclei. Of these 20 nuclei (12 pigmented and 8 unpigmented) are involved in 2 or all 3 cases. It is noticed that the distribution of Lewy bodies in Parkinson's disease described here corresponds surprisingly well to that of monoamine (dopamine, noradrenaline and serotonin) cell bodies demonstrated in rats by the histochemical fluorescence method. This correlation is similar to that of Alzheimer's neurofibillary changes in postencephalitic Parkinsonism as described by Ishii. Inasmuch as these viewpoints are also in agreement with preciously reported biochemical data on Parkinsonism, it is suggested that Parkinsonism (idiopathic and postencephalitic) should represent a system degeneration of monoamine neuron systems.
对3例帕金森病患者的中枢和外周神经系统进行的系统研究表明，路易小体存在于27个核中。其中20个核（12个有色核和8个无色核）在2例或所有3例中都有累及。值得注意的是，此处描述的帕金森病中路易小体的分布与通过组织化学荧光法在大鼠中显示的单胺（多巴胺、去甲肾上腺素和血清素）细胞体的分布惊人地吻合。这种相关性类似于石井所描述的脑炎后帕金森病中的阿尔茨海默神经原纤维变化。鉴于这些观点也与先前报道的帕金森病生化数据一致，有人提出帕金森病（特发性和脑炎后）应代表单胺神经元系统的系统性退化。
