Milne D B, Johnson L K, Mahalko J R, Sandstead H H
Am J Clin Nutr. 1983 May;37(5):768-73. doi: 10.1093/ajcn/37.5.768.
Folate and iron status was monitored at monthly intervals in 40 adult males who were living in a metabolic unit for 2 to 8 months and consuming diets containing 150 to 250 micrograms of folate per day. There were significant (p less than 0.02) declines in hematocrit, serum folate, and serum ferritin. Men who participated in studies for 6 months or more or those with initial serum folate levels more than 10.5 ng/ml and erythrocyte folate levels more than 481 ng/ml also exhibited a highly significant (p less than 0.001) decline in red blood cell folate. Men with erythrocyte folate below 480 ng/ml or serum folate below 10 ng/ml and who participated in the studies for less than 5 months showed little or no change in folate status. The findings may reflect adjustments in body folate to reflect dietary intakes. Also a folate intake of 200 +/- 68 micrograms/day appeared to be adequate for maintenance of folate stores in adult males. A correlation between iron stores and folate status was also observed. However, this relationship may be coincidental.
对40名成年男性的叶酸和铁状态进行了每月一次的监测，这些男性在代谢单元生活2至8个月，每日饮食中叶酸摄入量为150至250微克。血细胞比容、血清叶酸和血清铁蛋白均有显著下降（p<0.02）。参与研究6个月及以上的男性，或初始血清叶酸水平高于10.5 ng/ml且红细胞叶酸水平高于481 ng/ml的男性，其红细胞叶酸也有极显著下降（p<0.001）。红细胞叶酸低于480 ng/ml或血清叶酸低于10 ng/ml且参与研究少于5个月的男性，叶酸状态几乎没有变化。这些发现可能反映了身体叶酸对饮食摄入量的调整。此外，每日200±68微克的叶酸摄入量似乎足以维持成年男性的叶酸储备。还观察到铁储备与叶酸状态之间存在相关性。然而，这种关系可能是巧合。
