长春地辛持续输注治疗晚期头颈癌。
Continuous vindesine infusion in advanced head and neck cancer.
作者信息
Popkin J D, Bromer R H, Vaughan C W, Byrne R E, Licciardello J T, Hoffer S M, Welch J M, Fofonoff S A, Strong M S, Hong W K
出版信息
Am J Clin Oncol. 1983 Jun;6(3):301-4. doi: 10.1097/00000421-198306000-00008.
Abstract
Sixteen patients with advanced squamous cell carcinoma of the head and neck were treated with a 48-hour I.V. vindesine infusion. The dosage was 3 mg/m2/48 hours every 2 weeks. Toxicity consisted of leukopenia, paresthesias, and phlebitis. Major objective responses were seen in four patients (one CR, three PR), with a median duration of 4 months.
摘要
16例晚期头颈部鳞状细胞癌患者接受了48小时的长春地辛静脉输注治疗。剂量为每2周3mg/m²/48小时。毒性反应包括白细胞减少、感觉异常和静脉炎。4例患者出现主要客观缓解（1例完全缓解，3例部分缓解），中位缓解持续时间为4个月。
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