Iglesias C G, Torres V E, Offord K P, Holley K E, Beard C M, Kurland L T
Am J Kidney Dis. 1983 May;2(6):630-9. doi: 10.1016/s0272-6386(83)80044-4.
Between January 1, 1935 and December 31, 1980, adult polycystic kidney disease (APKD) was diagnosed in 40 residents of Olmsted County, Minnesota, resulting in an age- and sex-adjusted annual incidence rate of 1.38/100,000 person-years. In addition, 16 cases were detected at autopsy, increasing the rate to 2.06. It is estimated that 16 additional cases would have been discovered had all deaths come to autopsy, resulting in a rate of 2.75, or approximately twice the incidence rate of cases diagnosed during life. Because of improvements in medical care and diagnostic techniques, APKD has been diagnosed earlier and more frequently in the recent decades. This, along with therapeutic advances, explains the improvement in kidney and patient survival for the patients diagnosed during 1956-1980, as compared to those diagnosed during 1935-1955. Normotension at diagnosis tended to be associated with better kidney and/or patient survival. Cardiovascular disease was the leading cause of death.
1935年1月1日至1980年12月31日期间，明尼苏达州奥尔姆斯特德县的40名居民被诊断患有成人多囊肾病（APKD），年龄和性别调整后的年发病率为1.38/100,000人年。此外，尸检时发现了16例病例，使发病率提高到2.06。据估计，如果所有死亡病例都进行尸检，还会发现另外16例病例，发病率将达到2.75，约为生前诊断病例发病率的两倍。由于医疗护理和诊断技术的进步，近几十年来APKD的诊断时间更早、频率更高。这与治疗进展一起，解释了1956 - 1980年期间诊断出的患者与1935 - 1955年期间诊断出的患者相比，肾脏和患者生存率有所提高的原因。诊断时血压正常往往与更好的肾脏和/或患者生存率相关。心血管疾病是主要死因。
