Kasupski G J, Leers W D
Am J Med Sci. 1983 May-Jun;285(3):28-33. doi: 10.1097/00000441-198305000-00005.
Three cases of presumed respiratory syncytial virus (RSV) pneumonia in immunocompromised adults are described. Two patients had symptoms of cough, fever, and malaise, following completion of a course of combination chemotherapy for the treatment of acute lymphoblastic leukemia. The third patient, a juvenile onset diabetic, developed similar symptoms while hospitalized for severe hyperglycemia. Chest roentgenograms showed lower lobe infiltrates in both leukemic patients and a bilateral non-confluent bronchopneumonia in the diabetic patient. All patients had a marked rise in complement-fixing antibody titres to RSV, suggesting a concurrent infection with the virus. Extensive microbiological investigations failed to reveal any other etiologic agent. Nosocomial infection was considered possible. RSV is not considered a cause of pneumonia in compromised adults. Our three cases suggest that there may be a higher incidence of RSV pneumonia in compromised patients, than previously recognized.
本文描述了3例免疫功能低下成人患者疑似感染呼吸道合胞病毒（RSV）肺炎的病例。其中2例急性淋巴细胞白血病患者在完成联合化疗疗程后，出现咳嗽、发热和全身不适症状。第3例患者为青少年起病的糖尿病患者，因严重高血糖住院期间出现了类似症状。胸部X线片显示，2例白血病患者下叶有浸润影，糖尿病患者为双侧不融合性支气管肺炎。所有患者针对RSV的补体结合抗体滴度均显著升高，提示同时感染了该病毒。广泛的微生物学检查未发现任何其他病原体。考虑存在医院感染的可能。一般认为RSV并非免疫功能低下成人肺炎的病因。我们的这3例病例提示，免疫功能低下患者发生RSV肺炎的几率可能比之前认为的更高。
