DNA distribution and chromosome number in human cervical carcinoma.

The degree of ploidy of 15 human cervical carcinomas was investigated by use of flow cytometry and cytogenetic analysis. All tumors contained aneuploid cell populations. The results showed no correlation between ploidy and the clinical stage of the tumor. A high correlation was found between modal DNA content and modal chromosome number of the aneuploid cell populations, and it is concluded that flow cytometric analyses reflect the occurrence of tumor stemlines.