Cohn J N
Ann Intern Med. 1983 May;98(5 Pt 2):806-9. doi: 10.7326/0003-4819-98-5-806.
Increases in vascular tone induced by an increase in cytosol calcium concentration may be important in the development of hypertension, myocardial ischemia, and other cardiovascular disorders. A heterogeneous group of compounds known as calcium entry blockers inhibit smooth muscle contraction induced by physiologic and pharmacologic stimuli by blocking transmembrane transport of calcium through membrane channels. These drugs may reduce blood pressure through effects on the heart, the venous capacitance vessels, the arterial resistance vessels, and the renin-angiotensin system. Although their efficacy in antihypertensive therapy may eventually prove to be nonspecific, their ability to interfere with a basic cellular mechanism for vasoconstriction makes these drugs attractive as potential specific treatment for the abnormal vasomotion in patients with hypertension.
细胞溶质钙浓度升高所诱导的血管张力增加，可能在高血压、心肌缺血及其他心血管疾病的发生发展中起重要作用。一类被称为钙通道阻滞剂的异质性化合物，通过阻断钙经膜通道的跨膜转运，抑制由生理和药理刺激所诱导的平滑肌收缩。这些药物可通过作用于心脏、静脉容量血管、动脉阻力血管及肾素-血管紧张素系统来降低血压。尽管它们在抗高血压治疗中的疗效最终可能被证明是非特异性的，但它们干扰血管收缩基本细胞机制的能力，使这些药物作为高血压患者异常血管运动的潜在特异性治疗方法具有吸引力。
