Messerli F H
J Natl Med Assoc. 1989 Jan;81(1):17-23.
The pathophysiology and course of hypertensive cardiovascular disease in the black population differ significantly from those of nonblacks. The hemodynamic and endocrine profiles are different, consequences of hypertension are more severe in blacks, and black patients are often less responsive to standard antihypertensive treatment. Safe and efficacious treatment can be achieved when drug therapy is directed at the specific underlying pathophysiologic abnormality in black patients. By closely matching cardiovascular pathophysiologic findings in a given patient with the pharmacologic effects of an antihypertensive agent, blood pressure can often be controlled with fewer adverse effects. In addition, blood flow to target organs and their function can be maintained or improved. Calcium channel blockers are especially well suited for the treatment of essential hypertension in black patients.
黑人高血压性心血管疾病的病理生理学和病程与非黑人有显著差异。血流动力学和内分泌特征不同，高血压在黑人中的后果更严重，并且黑人患者对标准抗高血压治疗的反应通常较差。当药物治疗针对黑人患者特定的潜在病理生理异常时，可实现安全有效的治疗。通过将特定患者的心血管病理生理发现与抗高血压药物的药理作用紧密匹配，通常可以用较少的不良反应控制血压。此外，还可以维持或改善靶器官的血流及其功能。钙通道阻滞剂特别适合治疗黑人患者的原发性高血压。
