Hasan F M, Gehshan A, Fuleihan F J
Arch Environ Health. 1983 Mar-Apr;38(2):76-80. doi: 10.1080/00039896.1983.10543984.
Following acute exposure to chlorine gas, 18 asymptomatic subjects were evaluated for early pulmonary dysfunction. Airway obstruction was evident in all exposed individuals immediately after chlorine exposure. The severity, course of the obstructive defect, and clinical picture correlated with the chief complaint on admission. The obstructive abnormalities resolved within 1 wk after exposure to chlorine in 12 subjects whose chief complaint was cough. A slower resolution of the physiologic changes, clinical signs, and symptoms was noted in 6 subjects whose initial chief complaint was dyspnea. In this group, maximum mid-expiratory flow rate (FEF25-75%), and forced expiratory flow after exhaling 50% and 75% of the vital capacity (FEF50% and FEF25%, respectively) were still diminished 2 wk after chlorine exposure. The slow rate of resolution in the dyspnea group is best explained by increased individual susceptibility since a past medical history of smoking or asthma and "wheezing" was more prevalent in this group.
在急性接触氯气后，对18名无症状受试者进行了早期肺功能障碍评估。所有接触氯气的个体在接触后立即出现气道阻塞。阻塞性缺陷的严重程度、病程及临床表现与入院时的主要症状相关。12名主要症状为咳嗽的受试者在接触氯气后1周内阻塞性异常消失。6名最初主要症状为呼吸困难的受试者生理变化、临床体征及症状的缓解较慢。在该组中，接触氯气2周后，最大呼气中期流速（FEF25 - 75%）以及呼出肺活量的50%和75%后的用力呼气流量（分别为FEF50%和FEF25%）仍降低。呼吸困难组缓解缓慢的情况最好用个体易感性增加来解释，因为该组中吸烟或哮喘及“喘息”的既往病史更为普遍。
