Gleysteen J J, Barboriak J J
Arch Surg. 1983 Jun;118(6):681-4. doi: 10.1001/archsurg.1983.01390060003001.
Fasting blood levels of three lipid classes (high-density lipoprotein-cholesterol [HDL-C], total cholesterol, and triglycerides) were measured in morbidly obese patients before, and six and 12 months after, Roux-en-Y gastric bypass. Weight above ideal in 31 women averaged 72 kg, and in 12 men, 78 kg. Excess weight lost after six months was 49.7%. Total cholesterol levels and abnormally high triglyceride levels (183 +/- 106 mg/dL [SD]) decreased and became normal after six months. Low-normal HDL-C levels in 31 women (45 +/- 13 mg/dL) improved by six months to 54 +/- 19 mg/dL; similarly, HDL-C levels in 12 men (38 +/- 9 mg/dL) increased to 57 +/- 17 mg/dL. One of eight diabetic patients remained hyperglycemic; ten of 15 patients who were hypertensive, requiring medication preoperatively, became normotensive by six months. Lipid levels measured again at one year showed little change. Risk factors of coronary heart disease were improved by gastric bypass in these morbidly obese patients, and the changes were clearly established by six months after operation.
在病态肥胖患者中，于接受Roux-en-Y胃旁路手术前、术后6个月和12个月测量了三种脂质类别的空腹血水平（高密度脂蛋白胆固醇[HDL-C]、总胆固醇和甘油三酯）。31名女性超出理想体重的平均值为72千克，12名男性超出理想体重的平均值为78千克。6个月后体重减轻了49.7%。6个月后，总胆固醇水平以及异常高的甘油三酯水平（183±106毫克/分升[标准差]）下降并恢复正常。31名女性低至正常范围的HDL-C水平（45±13毫克/分升）在6个月时升至54±19毫克/分升；同样，12名男性的HDL-C水平（38±9毫克/分升）升至57±17毫克/分升。8名糖尿病患者中有1人仍患有高血糖；15名术前需要药物治疗的高血压患者中有10人在6个月时血压恢复正常。在1年时再次测量的脂质水平几乎没有变化。胃旁路手术改善了这些病态肥胖患者的冠心病危险因素，且这些变化在术后6个月时已明确显现。
