Morselt A F, Peereboom-Stegeman J H, Puvion E, Maarschalkerweerd V J
Arch Toxicol. 1983 Feb;52(2):99-108. doi: 10.1007/BF00354770.
With quantitative techniques at electron microscopical level chromatin condensation and emptying of the interchromatin space have been established in the nuclei of the endothelial cells of small uterine vessels. The nuclear and cytoplasmic changes after cadmium administration show much similarity between endothelial cells of small uterine vessels and cultured liver parenchymal cells. Cytoplasmic changes in both cell types after cadmium administration are suggestive of a disturbance in ribosomal RNA synthesis as the main cause leading to ultimate cell lysis.
运用电子显微镜水平的定量技术，已证实子宫小血管内皮细胞核中存在染色质浓缩和核间空间清空现象。给予镉后，子宫小血管内皮细胞与培养的肝实质细胞的核及细胞质变化表现出诸多相似性。给予镉后，两种细胞类型的细胞质变化提示核糖体RNA合成紊乱是导致最终细胞裂解的主要原因。
