Peereboom-Stegeman J H, Jongstra-Spaapen E J
Toxicology. 1979 Aug;13(3):199-213.
A light microscopical and ultrastructural survey of the early effects of cadmium chloride in the uterus of the prepubertal rat was performed. 3 h after injection of CdCl2 evidence of injury to the microcirculation was ultrastructurally apparent. The phenomena consisted of nuclear and nucleolar changes, extensive pinocytotic activity, vacuolisation of the cytoplasmic matrix, distension of the cisternae of the endoplasmic reticulum and an increase in cytoplasmic protrusions in the lumen of the cell. After 6 h the damage had increased and a certain portion of the endothelial cells showed signs of degeneration. At 24 h the changes were maximal and extruded red cells were observed in the interstitial tissue by light microscopy. At 48 h recovery had started and the situation appeared to return to normal.
对青春期前大鼠子宫中氯化镉早期作用进行了光学显微镜和超微结构研究。注射氯化镉3小时后，超微结构上明显可见微循环损伤迹象。这些现象包括细胞核和核仁变化、广泛的胞饮活动、细胞质基质空泡化、内质网池扩张以及细胞腔内细胞质突起增加。6小时后损伤加重，部分内皮细胞出现变性迹象。24小时时变化最大，光学显微镜下观察到间质组织中有挤出的红细胞。48小时时开始恢复，情况似乎恢复正常。
