Smulyan H, Csermely T J, Mookherjee S, Warner R A
Arteriosclerosis. 1983 May-Jun;3(3):199-205. doi: 10.1161/01.atv.3.3.199.
This report describes a noninvasive method by which the volume distensibility of forearm arteries can be calculated from direct measurements of pulse wave velocity. Such measurements are made at a variety of transmural arterial pressures (TMP) accomplished by placing the forearm in a cylinder and changing the pressures within. This technique eliminates arterial blood pressure as a variable, which strongly influences arterial distensibility. We studied 48 asymptomatic men and women, ages 21 to 98 years. There was considerable scatter, but significant positive relationships were demonstrated between increasing arterial distensibility and age at ambient and lower TMPs. This finding can be explained by an age-related reduction in arterial luminal diameter and an increase in arterial wall thickness which reduces arterial wall tension and more than offsets the increased stiffness produced by changes in wall composition. In six subjects, pulse tracings were simultaneously recorded on paper and analog tape. The taped curves were digitized and subjected to Fourier analysis to determine the wave velocity of individual harmonics. The characteristic wave velocity was defined and found comparable to the hand method used in the same beats (regression coefficient = + 0.97). These data indicate that the automatic and manual methods measured the same variable.
本报告描述了一种非侵入性方法，通过该方法可根据脉搏波速度的直接测量值计算前臂动脉的容积扩张性。此类测量是在多种跨壁动脉压（TMP）下进行的，通过将前臂置于一个圆筒中并改变其中的压力来实现。该技术消除了作为变量的动脉血压，而动脉血压会强烈影响动脉扩张性。我们研究了48名年龄在21至98岁之间的无症状男性和女性。数据存在相当大的离散性，但在环境压力和较低TMP下，动脉扩张性增加与年龄之间呈现出显著的正相关关系。这一发现可以通过与年龄相关的动脉管腔直径减小和动脉壁厚度增加来解释，动脉壁厚度增加会降低动脉壁张力，并且足以抵消因壁成分变化导致的硬度增加。在6名受试者中，同时在纸上和模拟磁带上记录了脉搏描记图。将磁带上的曲线数字化并进行傅里叶分析，以确定各个谐波的波速。定义了特征波速，并发现其与同一搏动中使用的手动方法测得的结果相当（回归系数 = +0.97）。这些数据表明自动方法和手动方法测量的是同一个变量。
