Varghese A J
Biochem Biophys Res Commun. 1983 May 16;112(3):1013-20. doi: 10.1016/0006-291x(83)91719-9.
The hydroxylamine derivative of misonidazole reacts with glutathione under physiological conditions to form two isomeric conjugates. Based on physical and chemical properties, the two conjugates have been identified as 1-[2-amino-(4-glutathion-S-yl)-1-imidazolyl]-3-methoxypropanol and 1-[2-amino-(5-glutathion-S-yl)-1-imidazolyl]-3-methoxypropanol. The formation of the glutathione conjugates of reduced misonidazole offers a molecular mechanism for the depletion of GSH in mammalian cells after exposure to misonidazole under hypoxic conditions.
米索硝唑的羟胺衍生物在生理条件下与谷胱甘肽反应形成两种异构共轭物。根据物理和化学性质，这两种共轭物已被鉴定为1-[2-氨基-（4-谷胱甘肽-S-基）-1-咪唑基]-3-甲氧基丙醇和1-[2-氨基-（5-谷胱甘肽-S-基）-1-咪唑基]-3-甲氧基丙醇。还原型米索硝唑的谷胱甘肽共轭物的形成，为低氧条件下暴露于米索硝唑后哺乳动物细胞中谷胱甘肽的消耗提供了一种分子机制。
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