球体和肿瘤中缺氧细胞的荧光免疫组化检测。
Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.
作者信息
Raleigh J A, Miller G G, Franko A J, Koch C J, Fuciarelli A F, Kelly D A
机构信息
Radiobiology, Cross Cancer Institute, Edmonton, Alberta, Canada.
出版信息
Br J Cancer. 1987 Oct;56(4):395-400. doi: 10.1038/bjc.1987.213.
Abstract
Polyclonal antibodies have been raised in rabbits to a haemocyanin adduct of a reductively-activated, fluorinated analogue of misonidazole. Fluorescence immunohistochemical studies show that the polyclonal antibodies bind to spheroid sections and tumour sections in patterns similar to those revealed by autoradiographic studies with a tritium-labelled derivative of the fluorinated misonidazole analogue.
摘要
已在兔体内产生针对米索硝唑还原激活的氟化类似物的血蓝蛋白加合物的多克隆抗体。荧光免疫组织化学研究表明，多克隆抗体与球体切片和肿瘤切片的结合模式，类似于用氟化米索硝唑类似物的氚标记衍生物进行放射自显影研究所显示的模式。
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