米索硝唑在单层和球体培养中与缺氧细胞的结合：侧链标记物与环标记物结合效率相同的证据。
Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label.
作者信息
Raleigh J A, Franko A J, Koch C J, Born J L
出版信息
Br J Cancer. 1985 Feb;51(2):229-35. doi: 10.1038/bjc.1985.33.
Abstract
The binding of ring-labelled and side-chain labelled misonidazole to hypoxic cells in monolayer and spheroid cultures of mammalian cells has been compared. The kinetics and patterns of binding for the two labelled compounds are indistinguishable. This finding has implications for the mechanism of binding and for the design of misonidazole analogues which might be used to identify hypoxic zones in tumours.
摘要
已比较了环标记和侧链标记的米索硝唑与哺乳动物细胞单层和球体培养物中缺氧细胞的结合情况。两种标记化合物的结合动力学和模式无法区分。这一发现对结合机制以及可能用于识别肿瘤中缺氧区域的米索硝唑类似物的设计具有重要意义。
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Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label.米索硝唑在单层和球体培养中与缺氧细胞的结合：侧链标记物与环标记物结合效率相同的证据。
Br J Cancer. 1985 Feb;51(2):229-35. doi: 10.1038/bjc.1985.33.
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本文引用的文献
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A marker for hypoxic cells in tumours with potential clinical applicability.一种具有潜在临床应用价值的肿瘤缺氧细胞标志物。
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Binding of misonidazole to EMt6 and V79 spheroids.米索硝唑与EMt6和V79球体的结合。
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):737-9. doi: 10.1016/0360-3016(82)90724-6.
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Binding of 14C-misonidazole to hypoxic cells in V79 spheroids.14C-米索硝唑与V79球体中缺氧细胞的结合。
Br J Cancer. 1982 May;45(5):694-9. doi: 10.1038/bjc.1982.110.
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Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells.厌氧细菌与低氧中国仓鼠肺成纤维细胞（V-79-473）中米索硝唑的代谢比较
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Reductive activation of nitroaromatics and enzyme inhibition: misonidazole and xanthine oxidase.硝基芳烃的还原活化与酶抑制：米索硝唑与黄嘌呤氧化酶
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Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.米索硝唑与缺氧哺乳动物细胞代谢诱导结合的特征
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