Hoffman R W, Yang H K, Waggie K S, Durham J B, Burge J R, Walker S E
Arthritis Rheum. 1983 May;26(5):645-52. doi: 10.1002/art.1780260511.
To define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/l, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRL/Mp--lpr/lpr, C57BL/6J--lpr/lpr, and normal control strains. Eighty-seven percent of MRL/l and MRL/n mice had typical band keratopathy; this was confirmed by histologic examination. Posterior uveitis was found in 35% of adult MRL/l mice. MRL substrains are potentially important models of ocular disease.
为了确定自身免疫性疾病小鼠的眼部异常情况，我们对MRL/l、MRL/n、NZB、NZB/NZW和帕尔默斯顿北小鼠进行了生物显微镜检查并检查了眼部组织。将结果与MRL/Mp-lpr/lpr、C57BL/6J-lpr/lpr和正常对照品系进行比较。87%的MRL/l和MRL/n小鼠患有典型的带状角膜病变；组织学检查证实了这一点。在35%的成年MRL/l小鼠中发现了后葡萄膜炎。MRL亚系可能是眼部疾病的重要模型。
