屈1,2 - 二氢二醇对映体及非对映体湾区屈1,2 - 二醇 - 3,4 - 环氧化物在小鼠皮肤和新生小鼠中的致瘤性。 - Suppr

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超能文献

Tumorigenicity of enantiomers of chrysene 1,2-dihydrodiol and of the diastereomeric bay-region chrysene 1,2-diol-3,4-epoxides on mouse skin and in newborn mice.

作者信息

Chang R L, Levin W, Wood A W, Yagi H, Tada M, Vyas K P, Jerina D M, Conney A H

出版信息

Cancer Res. 1983 Jan;43(1):192-6.

PMID:6847768

Abstract

摘要

相似文献

Tumorigenicity of enantiomers of chrysene 1,2-dihydrodiol and of the diastereomeric bay-region chrysene 1,2-diol-3,4-epoxides on mouse skin and in newborn mice.屈1,2 - 二氢二醇对映体及非对映体湾区屈1,2 - 二醇 - 3,4 - 环氧化物在小鼠皮肤和新生小鼠中的致瘤性。

Cancer Res. 1983 Jan;43(1):192-6.

Evidence for bay region activation of chrysene 1,2-dihydrodiol to an ultimate carcinogen.关于芘1,2 -二氢二醇的湾区活化形成最终致癌物的证据。

Cancer Res. 1978 Jun;38(6):1831-4.

Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis.在小鼠表皮中由甲基 Chrysene 立体选择性形成的对映体海湾区域二醇环氧化物的海湾区域甲基对新生小鼠和小鼠皮肤致瘤性的增强作用。

Cancer Res. 1987 Oct 15;47(20):5310-5.

High stereoselectivity among the optical isomers of the diastereomeric bay-region diol-epoxides of benz(a)anthracene in the expression of tumorigenic activity in murine tumor models.苯并(a)蒽的非对映体湾区二醇环氧化物的光学异构体在小鼠肿瘤模型中致瘤活性表达方面具有高度立体选择性。

Cancer Res. 1984 Mar;44(3):929-33.

Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice.四种旋光性湾区3,4-二醇1,2-环氧化物及氮杂环二苯并[c,h]吖啶的其他衍生物对小鼠皮肤和新生小鼠的致瘤性。

Carcinogenesis. 2000 Nov;21(11):1997-2003. doi: 10.1093/carcin/21.11.1997.

Tumorigenicity of bay-region epoxides and other derivatives of chrysene and phenanthrene in newborn mice.

Cancer Res. 1979 Dec;39(12):5063-8.

Mutagenicity and tumorigenicity of phenanthrene and chrysene epoxides and diol epoxides.

Cancer Res. 1979 Oct;39(10):4069-77.

Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin.5-甲基屈二氢二醇和二氢二醇环氧化物在新生小鼠及小鼠皮肤上的致瘤性

Cancer Res. 1985 Apr;45(4):1449-52.

Tumorigenicity of optical isomers of the diastereomeric bay-region 3,4-diol-1,2-epoxides of benzo(c)phenanthrene in murine tumor models.苯并[c]菲非对映体湾区3,4-二醇-1,2-环氧化物光学异构体在小鼠肿瘤模型中的致瘤性。

Cancer Res. 1986 May;46(5):2257-61.

Tumorigenicity of the diastereomeric benz[a]anthracene 3,4-diol-1,2-epoxides and the (+)- and (-)-enantiomers of benz[a]anthracene 3,4-dihydrodiol in newborn mice.非对映体苯并[a]蒽3,4 -二醇 - 1,2 - 环氧化物以及苯并[a]蒽3,4 - 二氢二醇的(+) - 和(-) - 对映体在新生小鼠中的致瘤性。

J Natl Cancer Inst. 1979 Jul;63(1):201-4.

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Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.并苯[a,h]蒽四个对映体 3,4-二羟基-1,2-环氧化物的致突变性和致癌性。

Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13.

Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat.环境污染物 6-硝基苊及其代谢物 (-)-[R,R]- 和 (+)-[S,S]-1,2-二羟基-1,2-二氢-6-硝基苊在大鼠中引起不同乳腺致癌性的机制。

Chem Res Toxicol. 2013 Apr 15;26(4):547-54. doi: 10.1021/tx300478z. Epub 2013 Mar 28.

Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell line.用 Aroclor 1254 处理的大鼠肝微粒体对环境性乳腺致癌物 6-硝基屈进行立体选择性代谢生成反式-1,2-二羟基-1,2-二氢-6-硝基屈，及其在 Laci 乳腺上皮细胞系中的比较突变图谱。

Chem Res Toxicol. 2009 Dec;22(12):1992-7. doi: 10.1021/tx9002897.

Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.苯并[a]芘湾区二醇环氧化物致瘤活性中双轴羟基与双赤道羟基的作用。

Proc Natl Acad Sci U S A. 1987 Dec;84(23):8633-6. doi: 10.1073/pnas.84.23.8633.

Metabolism of 6-nitrochrysene by intestinal microflora.肠道微生物群对6-硝基屈的代谢作用。

Appl Environ Microbiol. 1988 Jan;54(1):197-203. doi: 10.1128/aem.54.1.197-203.1988.

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