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[通过急性照射治疗哈丁-帕西黑色素瘤的可治愈性(作者译)]

[Curability of the Harding-Passey melanoma by means of acute irradiation (author's transl)].

作者信息

Kummermehr J C

出版信息

Strahlentherapie. 1978 Aug;154(8):578-81.

PMID:684779
Abstract

The curability of the transplantable Harding-Passey melanoma of the mouse was studied following acute irradiation under ambient and under anoxic conditions. The mean cure doses (44.1 and 56.1 Gy), the calculated fraction of hypoxic tumor cells (3%) and the slope of teh dose-effect curves do not revela any sign of enhanced radiation resistance in comparison with other animal tumors. As and additional finding, a high rate of radiation-induced mesenchymal skin tumors was ascertained in the NMRI-breed employée.

摘要

在环境条件和缺氧条件下对小鼠可移植性哈丁-帕西黑色素瘤进行急性照射后,研究了其可治愈性。平均治愈剂量(44.1和56.1戈瑞)、计算得出的缺氧肿瘤细胞比例(3%)以及剂量效应曲线的斜率,与其他动物肿瘤相比,未显示出任何辐射抗性增强的迹象。另外一项发现是,在使用的NMRI品系小鼠中确定了较高比例的辐射诱导间充质皮肤肿瘤。

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