Trott K R, Kummermehr J, Hug O, Lukacs S, Braun-Falco O
Strahlentherapie. 1978 Aug;154(8):571-7.
Radiation sensitivity of the hamster melanoma AMel 3 was studied in vivo and in vitro. In vitro, a dose-effect curve with the dose Do=155 rd and the extrapolation number 10 was obtained. In consideration of an oxygen enhancement factor of 2.5, the results of in-vivo examination with the quantitative transplantation method did not differ from in-vitro results. In living animals, about 40% of the tumor cells generally are hypoxic. These data do not verify the hypothesis of a particular radiation resistance of melanoma cells.
对仓鼠黑色素瘤AMel 3的辐射敏感性进行了体内和体外研究。在体外，获得了一条剂量效应曲线，其剂量Do = 155拉德，外推数为10。考虑到氧增强因子为2.5，定量移植法的体内检查结果与体外结果没有差异。在活体动物中，一般约40%的肿瘤细胞是缺氧的。这些数据并未证实黑色素瘤细胞具有特殊辐射抗性的假设。
