Herning R I, Jones R T, Benowitz N L, Mines A H
Clin Pharmacol Ther. 1983 Jan;33(1):84-90. doi: 10.1038/clpt.1983.12.
Indirect evidence suggests that smoking low-tar and nicotine cigarettes does not necessarily reduce exposure to these substances. Puff volume, duration and number, interpuff interval, and volume and duration of inhalation were measured while 11 subjects smoked two or four tobacco cigarettes. Nicotine blood levels and breath CO were measured before and after smoking. The machine-determined nicotine yields of the cigarettes correlated (r = 0.52) with the increase in nicotine blood levels after smoking but, when individual differences in smoking behavior were taken into account along with the nicotine yield, there was a stronger correlation with nicotine blood levels (r = 0.84 to 0.93).
间接证据表明，吸食低焦油和低尼古丁香烟并不一定能减少对这些物质的接触。在11名受试者吸食两支或四支香烟时，测量了每口的吸量、持续时间和次数、两口之间的间隔时间以及吸入的量和持续时间。在吸烟前后测量了血液中的尼古丁水平和呼出气体中的一氧化碳含量。机器测定的香烟尼古丁含量与吸烟后血液中尼古丁水平的升高相关（r = 0.52），但在考虑吸烟行为的个体差异以及尼古丁含量后，与血液中尼古丁水平的相关性更强（r = 0.84至0.93）。
