Ganina K P, Polishchuk L Z, Gritsenko A F, Kireeva S S
Tsitol Genet. 1978 May-Jun;12(3):257-62.
Direct analysis of karyotype revealed a heterogeneity of chromosome composition, variations in modal lines and chromosome aberrations, diversity of marker chromosome morphology. The variability of cytogenetic alterations was found in tumors both of the same and of different origin. These results established the nature of genome and chromosome alterations in the investigated tumors. The problem is discussed of a possible use of cytogenetic analysis for a more concrete characterization of human tumors in terms of their biological features.
核型直接分析显示染色体组成存在异质性、众数线变化和染色体畸变、标记染色体形态多样。在相同起源和不同起源的肿瘤中均发现了细胞遗传学改变的变异性。这些结果确定了所研究肿瘤中基因组和染色体改变的性质。讨论了细胞遗传学分析在根据人类肿瘤生物学特征更具体地表征肿瘤方面的可能用途问题。
