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[肿瘤转化导致细胞核“形态反应”和“定向反应”的变化]

[Changes in the "shape reaction" and "orientation reaction" of cell nuclei as a consequence of neoplastic transformation].

作者信息

Samoĭlov V I, Rovenskiĭ Iu A, Slavnaia I L, Slovachevskiĭ M S

出版信息

Tsitologiia. 1978 Mar;20(3):321-8.

PMID:684842
Abstract

Reactions of cell nuclei on curvature of cylindrical surfaces (curvature radii 333, 75 or 61 mcm) in 9 lines of cultured transformed human, Syrian hamster, rat and murine fibroblasts were studied quantitatively. The nuclear elongation was assessed as a ratio of long to short axes. Contact orientation was characterized by values derived from the angles, formed by long nuclear axes with the direction of cylinder axis. Due to transformation, cells lost the ability to elongate their nuclei in response to cultivation on cylindrical surfaces. The ability of cells cultured on cylindrical surfaces to increase the contact orientation values was also lost or weakened considerably.

摘要

研究了9株培养的转化人、叙利亚仓鼠、大鼠和小鼠成纤维细胞系的细胞核对圆柱面曲率(曲率半径分别为333、75或61微米)的反应。细胞核伸长率通过长轴与短轴的比值进行评估。接触方向由长核轴与圆柱轴方向所成角度得出的值来表征。由于转化,细胞失去了在圆柱面上培养时使细胞核伸长的能力。在圆柱面上培养的细胞增加接触方向值的能力也显著丧失或减弱。

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Tsitologiia. 1978 Mar;20(3):321-8.
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