Possati L, Ciarallo G, Collesi A, Rubini C
Microbiologica. 1983 Oct;6(4):339-46.
Eight cell lines obtained from BK virus-transformed hamster kidney cells were characterized by some biological parameters as presence of BKV T antigen, growth properties and tumourigenicity. The transforming ability of their DNA on primary foetal rat fibroblasts was then studied, and transformed rat cells were characterized by the same biological parameters as above. Transformed hamster cells showed no correlation among presence of virus, growth properties and tumourigenicity; DNA from normal hamster kidney cells and from two BKV-transformed cell lines induced transformation on rat fibroblasts, but presence of BKV T antigen was detected only in one DNA-transformed rat cell line. The role of cellular and viral genes on neoplastic transformation is discussed.
从BK病毒转化的仓鼠肾细胞获得的8个细胞系通过一些生物学参数进行了表征，如BK病毒T抗原的存在、生长特性和致瘤性。然后研究了它们的DNA对原代胎鼠成纤维细胞的转化能力，并用上述相同的生物学参数对转化的大鼠细胞进行了表征。转化的仓鼠细胞在病毒存在、生长特性和致瘤性之间没有相关性；来自正常仓鼠肾细胞和两个BK病毒转化细胞系的DNA诱导大鼠成纤维细胞发生转化，但仅在一个DNA转化的大鼠细胞系中检测到BK病毒T抗原。文中讨论了细胞和病毒基因在肿瘤转化中的作用。
