Ahlstedt S, Hessel B, Nilsson B S, Sohl-Akerlund A, Wedel I, Widström O
Int Arch Allergy Appl Immunol. 1983;70(1):92-5. doi: 10.1159/000233280.
The immunomodulating ability of fibrinogen fragment (Hol-DSK) and proteolytic enzyme with fibrinolytic activity from Aspergillus oryzae was analysed in CBA/Ca, C57Bl, C3H/HeJ and NMRI mice. Suppressive effects on the blastogenic response to mitogens were noted. No consistent suppressive effect, but sometimes an enhancing one, was recorded on the antibody responses to protein antigens. Administration of Hol-DSK or proteolytic enzyme shortly after the immunization resulted in a slight inhibition of the development of delayed hypersensitivity to picryl chloride in C57Bl but not in CBA mice. When similar administration was done simultaneously with administration of the challenging antigen of picryl chloride or sheep red blood cells in immunized mice, significant impairment of the delayed-type hypersensitivity reaction was noted. The modulating effects by Hol-DSK did not alter the in vitro bacteriocidal effects of peritoneal exudate cells from mice on Escherichia coli.
在CBA/Ca、C57Bl、C3H/HeJ和NMRI小鼠中分析了纤维蛋白原片段（Hol-DSK）和来自米曲霉的具有纤溶活性的蛋白水解酶的免疫调节能力。观察到对有丝分裂原刺激的增殖反应有抑制作用。对蛋白质抗原的抗体反应未观察到一致的抑制作用，但有时会有增强作用。免疫后不久给予Hol-DSK或蛋白水解酶会轻微抑制C57Bl小鼠对苦味酸氯的迟发型超敏反应的发展，但对CBA小鼠则无此作用。当在免疫小鼠中与苦味酸氯或绵羊红细胞的激发抗原同时进行类似给药时，观察到迟发型超敏反应明显受损。Hol-DSK的调节作用并未改变小鼠腹腔渗出细胞对大肠杆菌的体外杀菌作用。
