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Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses.不影响抗体反应的环磷酰胺剂量增强迟发型超敏反应。
J Exp Med. 1975 Mar 1;141(3):697-702. doi: 10.1084/jem.141.3.697.
2
Regulation of delayed-type hypersensitivity reactions by cyclophosphamide-sensitive T cells.环磷酰胺敏感T细胞对迟发型超敏反应的调节
J Immunol. 1978 Oct;121(4):1573-7.
3
Regulation of delayed-type hypersensitivity. III. Effect of cyclophosphamide on the suppressor cells for delayed-type hypersensitivity to sheep erythrocytes in mice.迟发型超敏反应的调节。III. 环磷酰胺对小鼠绵羊红细胞迟发型超敏反应抑制细胞的影响。
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Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: a possible initiating role of B cells.接触性超敏反应中早期需要补体激活以产生局部C5依赖性趋化活性，晚期需要T细胞干扰素γ：B细胞可能具有启动作用。
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10
T-cell lung granulomas induced by sepharose-coupled Mycobacterium tuberculosis protein antigens: immunosuppressive phenomena reversed with cyclophosphamide and indomethacin.琼脂糖偶联结核分枝杆菌蛋白抗原诱导的T细胞肺肉芽肿：环磷酰胺和吲哚美辛可逆转免疫抑制现象
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本文引用的文献

1
Studies on hypersensitivity. I. Delayed and Arthustype skin reactivity to protein conjugates in guinea pigs.超敏反应研究。I. 豚鼠对蛋白质结合物的迟发型和阿瑟斯型皮肤反应性
Immunology. 1959 Jan;2(1):53-63.
2
Immune response to chemically modified flagellin. II. Evidence for a fundamental relationship between humoral and cell-mediated immunity.对化学修饰鞭毛蛋白的免疫反应。II. 体液免疫与细胞介导免疫之间基本关系的证据。
J Exp Med. 1971 Jul 1;134(1):21-47. doi: 10.1084/jem.134.1.21.
3
Macrophage-digested antigen as inducer of delayed hypersensitivity.巨噬细胞消化的抗原作为迟发型超敏反应的诱导剂。
J Exp Med. 1971 Mar 1;133(3):494-505. doi: 10.1084/jem.133.3.494.
4
Selective priming of T cells by chemically altered cell antigens.通过化学改变的细胞抗原来选择性启动T细胞。
J Exp Med. 1972 Sep 1;136(3):656-61. doi: 10.1084/jem.136.3.656.
5
Suppressor cells in normal immunisation as a basic homeostatic phenomenon.正常免疫中的抑制细胞作为一种基本的稳态现象。
Nature. 1974 Apr 12;248(449):612-4. doi: 10.1038/248612a0.
6
Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.通过环磷酰胺选择性抑制抗体形成增强T细胞介导的免疫
J Exp Med. 1974 Jun 1;139(6):1529-39. doi: 10.1084/jem.139.6.1529.
7
Feedback inhibition of specifically sensitized lymphocytes.特异性致敏淋巴细胞的反馈抑制
J Exp Med. 1974 Mar 1;139(3):543-59. doi: 10.1084/jem.139.3.543.
8
Influence of dose and route of antigen injection on the immunological induction of T cells.抗原注射剂量和途径对T细胞免疫诱导的影响。
J Exp Med. 1974 Mar 1;139(3):528-42. doi: 10.1084/jem.139.3.528.
9
Preferential induction of cell-mediated immunity by chemically modified sheep erythrocytes.化学修饰的绵羊红细胞对细胞介导免疫的优先诱导作用。
Eur J Immunol. 1972 Apr;2(2):143-51. doi: 10.1002/eji.1830020210.
10
Activation of suppressor T cells by tumour cells and specific antibody.肿瘤细胞和特异性抗体对抑制性T细胞的激活作用。
Nature. 1974 Aug 16;250(467):594-6. doi: 10.1038/250594a0.

不影响抗体反应的环磷酰胺剂量增强迟发型超敏反应。

Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses.

作者信息

Askenase P W, Hayden B J, Gershon R K

出版信息

J Exp Med. 1975 Mar 1;141(3):697-702. doi: 10.1084/jem.141.3.697.

DOI:10.1084/jem.141.3.697
PMID:1117258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189708/
Abstract

Mice immunized with more SRBC than are required to produce optimal delayed-type hypersensitivity reactions, developed good antibody responses and poor delayed foot pad reactions. Cyclophosphamide treatment in low doses (20 mg/kg) before immunization, augmented the delayed-type hypersensitivity without affecting antibody responses. Cyclophosphamide did not augment delayed responses to optimal doses of SRBC (0.01%), but did augment the delayed hypersensitivity response of mice immunized with a suboptimal antigen dose (0.001%); which produced no detectable antibody response with or without cyclophosphamide pretreatment. These results suggest that antibody feedback is not the sole regulator of delayed reactions; the possibility that suppressor T cells may also be involved is discussed.

摘要

用比产生最佳迟发型超敏反应所需更多的绵羊红细胞（SRBC）免疫的小鼠，产生了良好的抗体反应，但迟发型足垫反应较差。免疫前用低剂量（20毫克/千克）的环磷酰胺处理，增强了迟发型超敏反应，而不影响抗体反应。环磷酰胺不会增强对最佳剂量SRBC（0.01%）的迟发型反应，但会增强用次优抗原剂量（0.001%）免疫的小鼠的迟发型超敏反应；无论有无环磷酰胺预处理，该剂量均未产生可检测到的抗体反应。这些结果表明，抗体反馈不是迟发型反应的唯一调节因子；文中还讨论了抑制性T细胞也可能参与其中的可能性。