Johnston G A
J Fam Pract. 1983 Jan;16(1):51-4.
Patients exposed prenatally to diethylstilbestrol have been shown to have a number of significant health risks that may be considered in the evaluation of this population. Neoplastic lesions of the cervix and vagina have been observed in a few patients. Increased prevalence of squamous intraepithelial neoplasms has been reported by several large clinical centers, and a recent observation of ovarian neoplasms has been reported. The significance of these observations remains to be substantiated. Anatomic deformities of the cervix, vagina, uterus, and fallopian tubes have been associated with increased pregnancy loss or infertility. The epithelial abnormalities of adenosis and cervical erosion essentially hallmark prenatal exposure to diethylstilbestrol. These changes are in themselves not malignant or premalignant and rarely warrant therapy (Figure 1).
已证明，产前接触己烯雌酚的患者存在许多重大健康风险，在评估该人群时可能需要考虑这些风险。在少数患者中观察到宫颈和阴道的肿瘤性病变。几个大型临床中心报告了鳞状上皮内瘤变的患病率增加，并且最近有关于卵巢肿瘤的观察报告。这些观察结果的意义仍有待证实。宫颈、阴道、子宫和输卵管的解剖畸形与妊娠丢失增加或不孕有关。腺病和宫颈糜烂的上皮异常基本上是产前接触己烯雌酚的标志。这些变化本身并非恶性或癌前病变，很少需要治疗（图1）。
