Nakamura S, Camins M B, Hochwald G M
J Neurosurg. 1983 Feb;58(2):198-203. doi: 10.3171/jns.1983.58.2.0198.
The resistance to cerebrospinal fluid (CSF) absorption through the alternative CSF absorption pathway in kaolin-induced hydrocephalic cats was measured by the constant infusion-manometric test. The cerebral ventricles were bypassed, and artificial CSF was infused directly into the central canal of the spinal cord. The infusion rates were increased stepwise from 0.022 to 0.168 ml/min when the capacity to absorb CSF was exceeded. There was an initial increase in resistance which was associated with the emergence of infusion fluid through a slit-like opening in the dorsal columns of the lower lumbar spinal cord. The resistance to flow decreased when the infusion rate was greater than 0.086 ml/min. Fluid accumulated in the spinal subarachnoid space when the ability to absorb was exceeded. The diversion of this fluid caused the pressure in the spinal cord central canal to fall rapidly. The results suggest that the CSF absorption deficit in chronic kaolin-induced hydrocephalic cats is probably caused by the restriction of CSF flow from the central canal through the spinal cord and into the spinal subarachnoid space. As a result of kaolin, the central canal is sufficiently dilated to permit, during infusion, the flow of at least five times as much CSF as the hydrocephalic cats produce. It is not clear whether the overloading of the CSF absorption mechanism is due to the restrictions imposed by the size of the subarachnoid space, or to the structures in this space involved with the return of CSF to the blood.
通过恒流测压试验测量高岭土诱导的脑积水猫经脑脊液（CSF）替代吸收途径吸收脑脊液的阻力。绕过脑室，将人工脑脊液直接注入脊髓中央管。当超过脑脊液吸收能力时，输注速率从0.022毫升/分钟逐步增加到0.168毫升/分钟。最初阻力增加，这与输注液通过腰髓下段背柱的缝隙样开口出现有关。当输注速率大于0.086毫升/分钟时，流动阻力降低。当超过吸收能力时，液体在脊髓蛛网膜下腔积聚。这种液体的分流导致脊髓中央管内压力迅速下降。结果表明，慢性高岭土诱导的脑积水猫脑脊液吸收缺陷可能是由于脑脊液从中央管通过脊髓流入脊髓蛛网膜下腔受到限制所致。由于高岭土的作用，中央管充分扩张，在输注过程中允许至少是脑积水猫产生脑脊液量五倍的脑脊液流动。目前尚不清楚脑脊液吸收机制的超负荷是由于蛛网膜下腔大小的限制，还是由于该空间中与脑脊液回流入血有关的结构所致。
