Rascher K, Booz K H, Donauer E, Nacimiento A C
Acta Neuropathol. 1987;72(3):248-55. doi: 10.1007/BF00691097.
A hydrocephalic-hydromyelic condition was induced in adult cats by causing the closure of the lateral apertures with intracisternal injections of kaolin. After displaying the symptoms characteristic of increased intracranial pressure, which lasted about 10-14 days but varied somewhat in intensity from animal to animal, the cats recovered. From approximately the 2nd post-operative week onward, a distended central canal was revealed by ventriculography; subsequently cavities developed in the tissue of the cord that communicated with the canal. Most cavities were located dorsal to the canal. The surfaces of the distended canal and the cavities showed that in ventral areas the ependyma streched but remained intact, whereas in dorsal areas it ruptured, exposing the nerve fibers to the cerebrospinal fluid (CSF). In cats which had been hydrocephalic for up to 2 years the walls of the cavities were covered by gliotic scar tissue; the nerve fibers were no longer exposed directly to the CSF.
通过向脑池内注射高岭土使侧孔闭合，在成年猫中诱发了脑积水 - 脊髓积水状况。在表现出持续约10 - 14天但不同动物强度有所差异的颅内压升高的典型症状后，猫恢复了。从术后大约第2周起，脑室造影显示中央管扩张；随后在脊髓组织中形成了与中央管相通的空洞。大多数空洞位于中央管的背侧。扩张的中央管和空洞的表面显示，在腹侧区域室管膜伸展但保持完整，而在背侧区域室管膜破裂，使神经纤维暴露于脑脊液（CSF）中。在脑积水长达2年的猫中，空洞壁被胶质瘢痕组织覆盖；神经纤维不再直接暴露于脑脊液。
