King B F
J Ultrastruct Res. 1983 Jan;82(1):1-18. doi: 10.1016/s0022-5320(83)90092-8.
Ultrastructural changes in the vaginal epithelium of the rhesus monkey during the menstrual cycle and pregnancy were studied by scanning and transmission electron microscopy. During the menstrual cycle, the epithelium was keratinized but varied in thickness. Cells of the basal and parabasal layers were polyhedral in shape but as they differentiated they accumulated glycogen and filaments. Cells in the intermediate layers had keratohyaline and membrane-coating granules. Cells in the superficial layers had a thickened cell envelope, abundant keratin filaments, electron-dense intercellular material, and focal tight junctions. The epithelial surface had numerous microridges and numerous adherent bacteria; bacteria were rare on desquamating cells. The epithelium remained keratinized for about the first month of gestation, then underwent "mucification." The cells contained abundant granules and Golgi apparatus. Concomitant with this transformation, bacteria were no longer adherent to the epithelial surface and the surface cells had microvilli instead of microridges. The epithelial changes during pregnancy were roughly associated with the changing pattern of steroid hormone secretion during gestation.
通过扫描电子显微镜和透射电子显微镜研究了恒河猴月经周期和孕期阴道上皮的超微结构变化。在月经周期中，上皮细胞发生角化，但厚度各异。基底层和副基底层细胞呈多面体形状，但在分化过程中会积累糖原和细丝。中间层细胞含有透明角质颗粒和膜包被颗粒。表层细胞有增厚的细胞膜、丰富的角蛋白细丝、电子致密的细胞间物质以及局灶性紧密连接。上皮表面有许多微嵴和大量黏附细菌；在脱落细胞上细菌很少见。上皮在妊娠的第一个月左右仍保持角化，然后经历“黏液化”。细胞含有丰富的颗粒和高尔基体。伴随这种转变，细菌不再黏附于上皮表面，表面细胞有微绒毛而非微嵴。孕期上皮的变化大致与孕期甾体激素分泌模式的变化相关。
