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甲喹酮滥用模式的变化。对246例死亡病例的调查。

Changing patterns of methaqualone abuse. A survey of 246 fatalities.

作者信息

Wetli C V

出版信息

JAMA. 1983 Feb 4;249(5):621-6.

PMID:6848871
Abstract

Of 246 methaqualone-related deaths identified during an 11-year period (1971 through 1981), 76% have occurred since 1977 and 72% have involved fatal trauma. One third of the victims died in vehicular crashes. Sharp increases in methaqualone-related traumatic suicides, nonvehicular accidents, and homicides have occurred since 1978. This report discusses demographic and toxicological findings, particularly in regard to counterfeit methaqualone. The pattern of fatal methaqualone abuse has changed from an overdose phenomenon in the early 1970s to one of traumatic death. Victims frequently have exhibited poor judgment, impulsive behavior, and somnolence while attempting to function in their environment. The socioeconomic impact of recreational methaqualone abuse should be curtailed by appropraite governmental action and restraint in the prescribing of methaqualone.

摘要

在1971年至1981年的11年期间确定的246例与甲喹酮相关的死亡病例中,76%发生在1977年以后,72%涉及致命创伤。三分之一的受害者死于车祸。自1978年以来,与甲喹酮相关的创伤性自杀、非交通事故和杀人案件急剧增加。本报告讨论了人口统计学和毒理学研究结果,特别是关于假冒甲喹酮的情况。致命性甲喹酮滥用模式已从20世纪70年代初的过量用药现象转变为创伤性死亡。受害者在试图在其环境中活动时经常表现出判断力差、冲动行为和嗜睡。娱乐性甲喹酮滥用的社会经济影响应通过政府的适当行动和对甲喹酮处方的限制加以遏制。

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