Hedges T R, Kenyon K R, Hanninen L A, Mosher D B
Arch Ophthalmol. 1983 Jan;101(1):64-8. doi: 10.1001/archopht.1983.01040010066010.
Monobenzone (the monobenzyl ether of hydroquinone [Benoquin]) is used topically by patients with extensive vitiligo to depigment their remaining normally pigmented skin. A patient who had been applying the drug for one year had an anterior linear deposition of pigment in both corneas. Of 15 additional patients with vitiligo, 11 of whom were using monobenzone, acquired conjunctival melanosis in two patients and pingueculae in three may have been related to monobenzone use. Light and electron microscopy of one corneal epithelial scraping and 12 conjunctival biopsy specimens revealed pleomorphic, single-membrane-limited intracytoplasmic inclusions within the corneal epithelium and within the epithelium, fibrocytes, histiocytes, and vascular endothelium of the conjunctiva. The ultrastructural aspects of these inclusions suggested that they are residual bodies containing lipid and lipofuscin.
对苯二酚单苯醚（对苯二酚的单苄醚[白癜净]）被广泛白癜风患者局部使用，以使其剩余的正常色素沉着皮肤脱色。一名使用该药物一年的患者双眼角膜前部出现线状色素沉着。在另外15名白癜风患者中，其中11人使用对苯二酚单苯醚，2例出现结膜黑变病，3例出现睑裂斑，可能与使用对苯二酚单苯醚有关。对一份角膜上皮刮片和12份结膜活检标本进行光镜和电镜检查，结果显示角膜上皮以及结膜的上皮、纤维细胞、组织细胞和血管内皮细胞内有形态多样、单膜包绕的胞质内包涵体。这些包涵体的超微结构特征表明它们是含有脂质和脂褐素的残余小体。
