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角膜和结膜的原位癌

Preinvasive carcinoma of the cornea and conjunctiva.

作者信息

Dark A J, Streeten B W

出版信息

Br J Ophthalmol. 1980 Jul;64(7):506-14. doi: 10.1136/bjo.64.7.506.

DOI:10.1136/bjo.64.7.506
PMID:7426564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043748/
Abstract

Greyish-white spots, varying in size, caused diagnostic problems in 2 patients with pre-invasive corneal carcinoma. Keratectomy specimens permitting light and electron microscopy indicated that the smaller spots predominating in one patient correlated with epithelial microcysts and vacuoles, while areas of parakeratosis accounted for the macroscopic white patches found in the other. A variety of ultrastructural abnormalities, including excessive basement membrane fibrillogenesis, were present in both cases.

摘要

灰白色斑点大小各异，给2例角膜原位癌患者带来了诊断难题。角膜切除术标本经光镜和电镜检查显示，其中1例患者以较小斑点为主，与上皮微囊肿和空泡相关，而另1例患者的肉眼可见白色斑块则由角化不全区域构成。两例均存在多种超微结构异常，包括基底膜纤维过度生成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/bfe4e52b953f/brjopthal00199-0046-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/c35ec65e6d71/brjopthal00199-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/58a13b64f38b/brjopthal00199-0040-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/39b20e96d167/brjopthal00199-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/0f52a08cd1f5/brjopthal00199-0041-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/9c8762b270dd/brjopthal00199-0041-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/0616bd417eb9/brjopthal00199-0041-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/64d9b1501783/brjopthal00199-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/36acece655e6/brjopthal00199-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/f1607762caab/brjopthal00199-0043-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/beeaa4c420ab/brjopthal00199-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/da8f14fc206c/brjopthal00199-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0db9/1043748/bfe4e52b953f/brjopthal00199-0046-a.jpg

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本文引用的文献

1
Diffuse epibulbar squamous-cell epithelioma.弥漫性眼球表面鳞状细胞上皮瘤
Am J Ophthalmol. 1967 Sep;64(3):Suppl:550-4. doi: 10.1016/0002-9394(67)90558-2.
2
Electron microscopic study of Bowen's disease.
Arch Dermatol. 1969 Jan;99(1):3-16.
3
The ultrastructure of preinvasive cancer of the corneal epithelium.角膜上皮原位癌的超微结构
Cancer Res. 1972 Jan;32(1):90-7.
4
Cystic disorders of the corneal epithelium. II. Pathogenesis.角膜上皮的囊性病变。II. 发病机制。
Br J Ophthalmol. 1973 Jun;57(6):376-90. doi: 10.1136/bjo.57.6.376.
5
Cogan's microcystic dystrophy of the cornea: ultrastructure and photomicroscopy.科根角膜微囊肿性营养不良：超微结构与光学显微镜检查
Br J Ophthalmol. 1978 Dec;62(12):821-30. doi: 10.1136/bjo.62.12.821.