Samaan N A, Ordonez N G, Ibanez M L, Goepfert H, Smith K
Arch Otolaryngol. 1983 Feb;109(2):91-4. doi: 10.1001/archotol.1983.00800160025006.
A patient with recurrent squamous carcinoma of the neck showed hypercalcemia with the immunoreactive parathyroid hormone (PTH) level within the upper limits of normal range, this being inappropriate for the degree of hypercalcemia. An immunoreactive peak of PTH was found in the tumor tissue extract, which appeared on column chromatography to be in the region of elution of pure bovine PTH. The tumor tissue showed positive immunoperoxidase reaction for PTH compared with negative reaction when the patient had normocalcemia. These findings are strong evidence that the tumor produced a PTHlike substance.
一名复发性颈部鳞状细胞癌患者出现高钙血症，其免疫反应性甲状旁腺激素（PTH）水平在正常范围上限，这与高钙血症程度不相符。在肿瘤组织提取物中发现了PTH免疫反应峰，在柱色谱上显示其洗脱区域与纯牛PTH相同。与患者血钙正常时的阴性反应相比，肿瘤组织对PTH呈免疫过氧化物酶阳性反应。这些发现有力地证明该肿瘤产生了一种PTH样物质。
