Nicolaides K H, Welch C C, MacPherson M B, Johnson I R, Filshie G M
Br J Obstet Gynaecol. 1983 May;90(5):475-9. doi: 10.1111/j.1471-0528.1983.tb08947.x.
Mechanical dilation of the cervix can be both difficult and dangerous and has potentially serious complications. Lamicel, a synthetic hydrophilic polymer, was inserted into the cervix between 2 and 24 h before termination by vacuum aspiration in the first trimester in 48 nulliparae. A control group of 12 nulliparae were not treated with Lamicel. The force needed to dilate the cervix, accurately measured with a specifically designed force-measuring instrument, was found to be significantly reduced in all treated groups. The greatest rate of dilatation occurred within the first 2 h after insertion.
子宫颈的机械扩张既困难又危险,且可能引发严重并发症。Lamicel是一种合成亲水性聚合物,在48例初产妇孕早期行真空吸引终止妊娠前2至24小时,将其插入子宫颈。设立了一个由12例初产妇组成的对照组,未接受Lamicel治疗。使用专门设计的测力仪器精确测量子宫颈扩张所需的力,结果发现所有治疗组的该力均显著降低。最大扩张速率发生在插入后的前2小时内。