Platz-Christensen J J, Nielsen S, Hamberger L
Department of Gynaecology and Obstetrics, Sahlgrenska University Hospital, Göteborg, Sweden.
Acta Obstet Gynecol Scand. 1995 Nov;74(10):809-12. doi: 10.3109/00016349509021202.
To study the effectiveness of three different cervical ripening agents in terms of dilatation ability and patient discomfort in connection with legal first trimester abortion.
Three randomized trials among unselected nulliparous women were performed 1: hygroscopic tent versus gemeprost, 2: misoprostol versus gemeprost and 3: misoprostol administered orally 17 versus 10 hours before vacuum curettage was performed.
Dilatation ability, frequent gastrointestinal side effects, severe pain (patients' perception).
In Trial 1, there was a tendency of a greater dilatation ability using the hygroscopic tent, while the experience of pain was a greater problem with gemeprost. In Trials 2 and 3, there were no significant differences in the dilatation abilities or gastrointestinal patient discomfort. There was a tendency towards a higher demand for narcotic analgesics in patients treated with gemeprost compared with all other groups.
Gemeprost and misoprostol showed almost identical ability to dilate and caused patient-experienced discomfort to the same degree. The use of misoprostol may be preferred as it has the advantage of being both less expensive and easier to administer.
研究三种不同的宫颈成熟剂在与合法的孕早期人工流产相关的扩张能力和患者不适方面的有效性。
在未选择的未生育妇女中进行了三项随机试验：1：吸湿扩张器与吉美前列素对比；2：米索前列醇与吉美前列素对比；3：在进行真空刮宫术前17小时与10小时口服米索前列醇对比。
扩张能力、频繁的胃肠道副作用、剧痛（患者感受）。
在试验1中，使用吸湿扩张器有更大扩张能力的趋势，而使用吉美前列素时疼痛体验是个更大的问题。在试验2和试验3中，扩张能力或胃肠道患者不适方面无显著差异。与所有其他组相比，使用吉美前列素治疗的患者对麻醉性镇痛药的需求有更高的趋势。
吉美前列素和米索前列醇显示出几乎相同的扩张能力，并且在相同程度上引起患者体验到的不适。米索前列醇的使用可能更受青睐，因为它具有价格更低且更易于给药的优势。
