Bakker-Grunwald T
Biochim Biophys Acta. 1983 Jun 10;731(2):239-42. doi: 10.1016/0005-2736(83)90014-7.
(1) The occurrence of volume-regulatory responses in isolated rat hepatocytes was investigated. After hypotonic shock, cells were able to shrink back to their normal volume within 15 min. By contrast, after hypertonic shock cells kept their shrunken volume for at least 15 min. (2) Na+-alanine cotransport increases K+ permeability in rat hepatocytes (Kristensen, L.O. (1980) J. Biol. Chem. 255, 5236-5243). It is shown here that this effect is due to cell swelling secondary to alanine accumulation rather than to the Na+-alanine cotransport itself.
(1) 研究了分离的大鼠肝细胞中体积调节反应的发生情况。低渗休克后，细胞能够在15分钟内回缩至正常体积。相比之下，高渗休克后，细胞在至少15分钟内保持收缩后的体积。(2) 钠-丙氨酸共转运增加大鼠肝细胞的钾通透性（克里斯蒂安森，L.O.（1980年）《生物化学杂志》255卷，5236 - 5243页）。此处表明，这种效应是由于丙氨酸积累导致的细胞肿胀，而非钠-丙氨酸共转运本身。
