Agnew J E, Bateman J R, Sheahan N F, Lennard-Jones A M, Pavia D, Clarke S W
Bull Eur Physiopathol Respir. 1983 Jan-Feb;19(1):37-41.
Inhaled radioaerosol particles have been used to assess mucus clearance in 12 patients with stable asthma. Patients who coughed frequently showed faster clearance than those who coughed infrequently. Treatment with medium and high dose oral corticosteroids reduced coughing and thereby reliance on mucus transport by cough. Despite this, and despite increased penetration of the particles into the bronchial tree, mean particle clearance was slightly faster after four week treatment (two weeks on 15 mg prednisolone orally each day, plus two weeks on 30 mg). Mean clearance remained, however, markedly slower than in normal subjects. Five patients who were initially sputum producers (mean 1.4 g . h-1) ceased to produce sputum after four week treatment.
吸入放射性气溶胶颗粒已被用于评估12例稳定期哮喘患者的黏液清除情况。频繁咳嗽的患者比不常咳嗽的患者清除速度更快。中高剂量口服糖皮质激素治疗减少了咳嗽，从而降低了对咳嗽介导的黏液转运的依赖。尽管如此，尽管颗粒在支气管树中的渗透增加，但在四周治疗后（每天口服15毫克泼尼松龙两周，再加每天口服30毫克两周），平均颗粒清除速度略快。然而，平均清除速度仍明显慢于正常受试者。5例最初有咳痰的患者（平均1.4克·小时-1）在四周治疗后停止咳痰。
