Fischer S M, Ogle S, Marnett L J, Nesnow S, Slaga T J
Cancer Lett. 1983 May;19(1):61-6. doi: 10.1016/0304-3835(83)90136-2.
Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis, in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.
丙二醛（MDA）是一种脂质过氧化产物，其被认为与致癌作用有关，部分原因在于其具有报道的诱变活性。因此，确定其作为完全致癌物、肿瘤启动剂或肿瘤促进剂的活性很有意义。使用SENCAR小鼠皮肤模型，发现纯丙二酸钠（NaMDA）在这些类别中均无活性。此外，在中国仓鼠V - 79代谢协同试验中，丙二酸钠被确定对促进剂呈阴性。
